{"id":2447,"date":"2022-09-29T15:31:18","date_gmt":"2022-09-29T15:31:18","guid":{"rendered":"https:\/\/redycomunicacion.com\/?p=2447"},"modified":"2023-12-15T09:06:58","modified_gmt":"2023-12-15T09:06:58","slug":"cbd-safe-and-effective","status":"publish","type":"post","link":"https:\/\/redycomunicacion.com\/index.php\/2022\/09\/29\/cbd-safe-and-effective\/","title":{"rendered":"CBD: Safe and effective?"},"content":{"rendered":"

CBD had no effects on cocaine-induced CPP, the rate of extinction of cocaine memory, or the drug-primed reinstatement (Chesworth and Karl, 2020). However, a recent report of our group demonstrated that CBD (30 and 60 mg\/kg, i.p.) significantly reduced cocaine priming- and social defeat-induced reinstatement of CPP (Calpe-Lopez et al., 2020). Likewise, Lujan et al. demonstrated that CBD (10 and 20 mg\/kg, i.p.) significantly attenuated cocaine-induced CPP. Furthermore, they employed an intravenous SA paradigm and showed that CBD (20 mg\/kg, i.p.) reduced the motivation to self-administer cocaine in a fixed ratio 1 schedule, as well as the breaking point during the progressive ratio stage. Also, it is relevant to point out that the effects of CBD on hippocampal neurogenesis plays a pivotal role in the reduction of cocaine SA (Luj\u00e1n et al., 2019). Recently, attenuating effects of CBD on the motivational properties of cocaine were also revealed by Galaj et al..<\/p>\n